If you compress air to a large enough pressure do new molecules form that have a large activation energy?
The average speed of the molecules depends on the temperature, not the pressure. That drives the energy available from collisions. On average, there is no more energy available at high pressure than at low pressure. At higher pressures, there will be more collisions, so ones at the top end of the energy spectrum become more common (as do all the others). That might help with reactions that just need a bit more energy. You also shift the equilibrium of reactions to the side that has fewer molecules, because driving that direction reduces the pressure.