Nature has particle accelerators that are far beyond our capacity, but occasionally I hear atomic physicists claim that they are able to make something that has never been formed in any natural process (that is, not coming from intelligent life). This has always seemed plausible to me, but is it really true?
For definiteness, let's say we have produced 100,000 atoms at 100 nK for 10 seconds, which is quite conservative in every parameter. What is the probability of this many atoms having ever taken this temperature for this amount of time due to spontaneous fluctuations, anywhere in the observable universe? How about 10 atoms? Supposing the universe is infinite in size, what volume would we have to look at before we had a decent probability of this ever occurring? Feel free to make any simplifying assumptions that would give an upper bound to this probability, such as assuming that the universe has been at 3 K the entire time since the Big Bang.
Edit: since no one has bitten, I will point out the farthest I've gotten on this question: the fluctuation theorem states, if I understand it correctly, that following:
$\text{Pr}(\Delta S=-S_{UC})=\text{Pr}(\Delta S=+S_{UC})e^{-S_{UC}t}$
where $S_{UC}$ is the entropy decrease needed to take the atoms from 3 K to 100 nK. In other words, it is exponentially more likely that they will spontaneously increase by the needed entropy, itself presumably an unlikely event.