To set the stage for what I want to discuss let me first discuss some specific examples.
I want to discuss at one hand Kepler's laws of celestial mechanics, and on the other hand newtonian mechancis plus the inverse square law of gravity.
We have that the move from Kepler's laws to the inverse square law of gravity was fundamental progress.
In doing so the description of physics taking place was moved to a higher level of abstraction.
Later there was Faraday's introduction of the concept of a field. Electric field and magnetic field. In terms of such a field concept the Coulomb force and magnetic force are thought of as being mediated by a field.
The existence of that field is a supposition. The field itself is not a measurable entity. What is measurable is how the supposed field is affecting motion of objects.
Example: the trajectories of particles as they show up in a cloud chamber. Usually a magnetic field is applied, so that charged particles are pulled to curvilinear motion. From the amount of effect that the magnetic field has on the particle properties of the particle can be inferred. The more precise the strength of the magnetic field is calibrated the more precise the inferences about the particle.
We see a recurring pattern. In many cases achievement of progress entailed moving the description to a higher level of abstraction. Correlated with that: a recurring pattern is that at higher levels of abstraction unification is achieved.
But the things that are accessible to measurement are not at the level of those abstractions.
The units of the SI system are - obviously - defined in terms of measurable quantities.
As we know, in 2019 a new standard for defining the kilogram was ratified. The machine that is specific to establishing the value of Planck's constant is called Kibble balance (Named after Bryan Kibble)
A Kibble balance performs a force measurement. Force is a measurable quantity, energy isn't a measurable.
Potential energy does not have an intrinsic zero point. There is freedom to put the zero point anywhere in the range. Whenever something involving a potential energy is measured the measurement is one of difference of potential. Difference of potential is a measurable, potential itself is not a measurable. Whenever a potential is used the aspect that is actually used is the derivative of the potential, not (the value of) the potential itself.
Kinetic energy is defined in terms of velocity, and we have the principle of relativity of inertial motion: velocity is relative. Kinetic energy of linear motion does not have an intrinsic zero point; the kinetic energy that we attribute to an object depends on the velocity that we attribute to the object. Kinetic energy of linear motion does not have an intrinsic zero point.
Of course, the reason that this whole arrangement works is that the inferred entities stand in a well defined relation to the measurable entities.
In the case of classical mechanics: key is that you can transform between on one hand representation in terms of force and acceleration and on the other hand representation in term of potential energy and kinetic energy.
The work-energy theorem provides that transformation.
Some months ago I went to the earliest PSE question about stationary action, and I submitted an answer in which I show how to go from F=ma to Hamilton's stationary action
The sequence from F=ma to Hamilton's stationary action has two stages:
-Derivation of the work-energy theorem from F=ma
-Demonstration that in cases where the work-energy theorem holds good Hamilton's stationary action will hold good also.