We are already living in a nearly empty de Sitter space - the cosmological constant already represents 73% of the energy density in the Universe - and the Universe won't experience any qualitative change in the future: the percentage will just approach 100%.
However, once the space may be approximated as an empty de Sitter space, all moments of time are physically equivalent. It's because de Sitter space belongs among the so-called "maximally symmetric spacetimes" - in which each point may be mapped to any other point by a symmetry transformation (isometry).
So nothing will change qualitatively: the radius of the cosmic horizon will converge towards those 100 billion light years or so and never change again; we are not far from that point.
Yes, it is true that de Sitter space is analogous to a black hole except that the interior of the black hole is analogous to the space behind the cosmic horizon - outside the visible Universe. The de Sitter space also emits its thermal radiation, analogous to the Hawking radiation. It's a radiation emitted from the cosmic horizon "inwards". Because the interior of the de Sitter patch is compact, unlike its black hole counterpart (the exterior of the black hole), the radiation is reabsorbed by the cosmic horizon after some time and the de Sitter space no longer loses energy.
While the right theoretical description of the thermal radiation in de Sitter space is a theoretician's puzzle par excellence (we are only "pretty sure" about the semiclassical limit, and don't even know whether there exists any description that is more accurate than that), it has absolutely no impact on observable physics because the typical wavelength of the de Sitter thermal radiation is comparable to the radius of the Universe. (Note that it's true for black holes, too: the wavelength of the Hawking radiation is mostly comparable to the black hole radius.)
Such low-energy quanta are obviously unobservable in practice - and in some sense, they're probably unobservable even in theory. You should imagine that there are just $O(1)$ thermal photons emitted by the cosmic horizons inside the visible cosmos whose energy is $10^{-60}$ Planck energies per photon. From an empirical viewpoint, it's ludicrous.