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I am currently reading up on the formation of $$\beta$$-sheets. The following text describes its formation from a free energy point of view:

The edge of a β-sheet consists of (a) edge β-strands, and (b) bends or loops connecting the β-strands [...]. Let the coil free energy be zero (i.e., the reference point); $$f_{\beta}$$ , the free energy of a residue in the center of the β-sheet; $$f_{\beta}$$ + $$\Delta f_{\beta}$$ , the free energy of an edge β-strand residue (i.e., $$f_{\beta}$$$$\Delta f_{\beta}$$ is the edge effect); and U, the free energy of a bend. Since the β-sheet forms, it is stable (i.e., $$f_{\beta}$$ < 0), and the edge effects prevent it from falling into pieces (i.e., $$\Delta f_{\beta}$$ > 0 and U > 0) (Finkelstein, Protein Physics)

Why do $$\Delta f_{\beta}$$ and U need to be positive? Wouldn't this mean that the bends or folds of the sheet are unstable? Why would negative $$\Delta f_{\beta}$$ and U make the sheet fall to pieces?

I am currently reading up on the formation of $$\beta$$-sheets. The following text describes its formation from a free energy point of view:

The edge of a β-sheet consists of (a) edge β-strands, and (b) bends or loops connecting the β-strands [...]. Let the coil free energy be zero (i.e., the reference point); $$f_{\beta}$$ , the free energy of a residue in the center of the β-sheet; $$f_{\beta}$$ + $$\Delta f_{\beta}$$ , the free energy of an edge β-strand residue (i.e., $$f_{\beta}$$ is the edge effect); and U, the free energy of a bend. Since the β-sheet forms, it is stable (i.e., $$f_{\beta}$$ < 0), and the edge effects prevent it from falling into pieces (i.e., $$\Delta f_{\beta}$$ > 0 and U > 0) (Finkelstein, Protein Physics)

Why do $$\Delta f_{\beta}$$ and U need to be positive? Wouldn't this mean that the bends or folds of the sheet are unstable? Why would negative $$\Delta f_{\beta}$$ and U make the sheet fall to pieces?

I am currently reading up on the formation of $$\beta$$-sheets. The following text describes its formation from a free energy point of view:

The edge of a β-sheet consists of (a) edge β-strands, and (b) bends or loops connecting the β-strands [...]. Let the coil free energy be zero (i.e., the reference point); $$f_{\beta}$$ , the free energy of a residue in the center of the β-sheet; $$f_{\beta}$$ + $$\Delta f_{\beta}$$ , the free energy of an edge β-strand residue (i.e., $$\Delta f_{\beta}$$ is the edge effect); and U, the free energy of a bend. Since the β-sheet forms, it is stable (i.e., $$f_{\beta}$$ < 0), and the edge effects prevent it from falling into pieces (i.e., $$\Delta f_{\beta}$$ > 0 and U > 0) (Finkelstein, Protein Physics)

Why do $$\Delta f_{\beta}$$ and U need to be positive? Wouldn't this mean that the bends or folds of the sheet are unstable? Why would negative $$\Delta f_{\beta}$$ and U make the sheet fall to pieces?

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# Free energy and stability

I am currently reading up on the formation of $$\beta$$-sheets. The following text describes its formation from a free energy point of view:

The edge of a β-sheet consists of (a) edge β-strands, and (b) bends or loops connecting the β-strands [...]. Let the coil free energy be zero (i.e., the reference point); $$f_{\beta}$$ , the free energy of a residue in the center of the β-sheet; $$f_{\beta}$$ + $$\Delta f_{\beta}$$ , the free energy of an edge β-strand residue (i.e., $$f_{\beta}$$ is the edge effect); and U, the free energy of a bend. Since the β-sheet forms, it is stable (i.e., $$f_{\beta}$$ < 0), and the edge effects prevent it from falling into pieces (i.e., $$\Delta f_{\beta}$$ > 0 and U > 0) (Finkelstein, Protein Physics)

Why do $$\Delta f_{\beta}$$ and U need to be positive? Wouldn't this mean that the bends or folds of the sheet are unstable? Why would negative $$\Delta f_{\beta}$$ and U make the sheet fall to pieces?