Addendum 2012-05-30.20:220 EST
Angular momentum
I skipped over angular momentum in defining the set of objects used to define the minimum energy SR frame. Unlike linear momentum, residual angular momentum in a set of object of course cannot be resolved simply by resetting the frame. Always interesting, angular momentum, since if it exists it necessarily "points" to additional matter that exists outside the current set, at least if you believe in absolute universal conservation of it (which I certainly do). Its energy can be quantified locally, though.
"Center of mass" in curved spaces
@LubošMotl and others brought up the excellent point that you can't really do a center of momentum for curved space. If you assume that the curved space can be embedded within a larger Euclidean space (Nash proved that in his last pre-breakdown paper, which was an amazing work), then it's easy to see that the center of mass of the curved piece is not very likely to fall within the piece itself. It's more likely to wind up somewhere "other" than the surface, e.g. for an ordinary balloon it falls at the center of the balloon! So, when I say "center of mass frame," I'm really using a sloppy shorthand for a procedure that would require following along the locally 3D surfaces to construct an overall average. Theorem: For any smooth manifold decorated with components that move locally in accordance to the accepted rules of mass, energy, and momentum conservation, and whose shape can be approximated as being invariant over the time scales considered for those motions, there exists a singular "manifold rest frame" that is motionless with respect both to (a) the overall form of the manifold if it is irregular, and (b) with respect to the SR energy minimum defined for the entire set of components moving within the manifold.
(I am dancing lightly over rotations in 4D; there are two orthogonal ones, makes life interesting. I'm also skipping over the issue of the two different forms of 4D holes, the equivalents of 1-spheres (rings) and of 2-spheres (balloons), on the assumption that such topologies are unlikely for a realistic universe.)
(All dimensional solids n>3 have more than one type of, each hole type having an equivalence to one of a series of lower dimensional spheres from the 1-sphere (ring) to the (m-2)-sphere. That's not counting erasures (m=n), splits (m=n-1), and internal voids (m=0) (Do they address that in string theory? If not, how do they specify or distinguish between the 7 or 8 hole types of the n=9 or n=10 spaces used in M-theory? Ah.. hmm... maybe I should make that into a real question?)