I am a firm believer of notion of wick rotation. As Lubos nicely pointed out, the most clear indication of wick rotation comes from quantum cosmology. In fact, many new recent results in different models of QGquantum gravity such as loop quantum gravity$^1$ ( see M.Bojowald,J.Mielczarek,A.Barrau,J.Grain, G.Calcagni and othersLQG) , CDTcausal dynamical triangulation$^2$ ( see Ambjorn,Coumbe, Gizbert-Studnicki and JurkieiwczCDT) , Nonnon-Commutative Geometry ( See Lizzi, Kurkiv , D'Andrea , ...) commutative geometry$^3$,Horava Horava-Lifshitz Gravity ( see Horava, Melby-Thomson, Kevin Crosvenor / see also K.Crosvenor lecture at GR21 conference 2016) $^4$, Causal Sets ( L.Glaser and S.Surya / also Glasercausal sets$^5$, D.O'Connor and Surya ; forthcoming) and eventually in Superstring-Msuperstring M- Theory ( C.Hull/ Edward Witten / Robbert Dijkgraaf, Ben Heidenreich, Patrick Jeffersontheory$^6$, Cumrun Vafa 2016) strongly indicate that at the very high curvatures near or at the Planck scale ( totallytotally non-perturbative quantum gravitational system ) the signature of spacetime is not anymore Lorentzian anymore and turns into a quantum version of 4D4-D Euclidean space which is timeless,Acausal acausal and devoidsdevoid of any dynamics or evolution , describing elegantly the so called No-Bondary Proposal of Hartle-Hawking).
Cheers
$^1$See M.Bojowald, J.Mielczarek, A.Barrau, J.Grain, G.Calcagni
$^2$See Ambjorn, Coumbe, Gizbert-Studnicki, and Jurkieiwcz
$^3$See Lizzi, Kurkiv, D'Andrea, and others
$^4$See Horava, Melby-Thomson, and Kevin Crosvenor, as well as the K. Crosvenor lecture at the GR21 conference 2016
$^5$See L. Glaser and S.Surya, as well as Glaser, D.O'Connor and Surya; forthcoming
$^6$See C.Hull, Edward Witten, Robbert Dijkgraaf, Ben Heidenreich, Patrick Jefferson, and Cumrun Vafa 2016