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It's not the making as opposed to verifying of topological superconductors that is difficult experimentally. One of the most useful techniques in identifying topological properties of a material is Angle-Resolved Photoemission Spectroscopy (ARPES). ARPES can independently image the bulk and surface modes of a 3-D solid with very good energy and momentum ...

As for the second question (are the Majorana difficult to realize in lab ?) the answer is obviously yes, and for the same reason that we have no idea what to look for ! (NB: of course there are some predictions about the experimental signature of the Majorana, but no smoking gun experiment.

This answer is only an order of magnitude estimation. The main uncertainty comes from the fact that for a constant current the cooling power is not determined by the superconducting wire but from the quality of the isolation against radiation, convection and conduction of warmer parts of the structure to the cold wire at 4.2K We can use the LHC ring as an ...