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Does the Breit Wigner formula apply to intermediate virtual particles?

Breit Wigner Formula describes the cross section for interactions that proceed dominantly via a intermediate particle (O*) A+B → O* → C + D: $$σ = \frac{2\Pi}{k^{2}}\frac{Γ_{i}Γ_{f}}{(E-E_{o})^{2} + ...