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In the case of a bubble, the outside pressure is less then the inside pressure.

If that is the case can bubbles exist in vacuum? I am not sure but this should be true if vacuum has zero pressure

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Surface tension... (Assuming a fluid that will not evaporate for the time scale that you care about.) –  dmckee Dec 23 '13 at 18:49
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Yes, a bubble can exist in vacuum. A bubble itself has surface tension which tries to minimize the surface area, i.e. tries to push inward. It is small compared with the atmosphere on Earth though. But in the vacuum, there is no pressure from the outside and very little pressure from the inside. Thus, the surface tension becomes significant.

The final shape will become equilibrium with the inner pressure. If the inner pressure is too large, the bubble will simply burst. That said, the pressure allowed inside is very small compared to the atmosphere.

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