Fusion happens between light nuclei. It cannot happen in room temperatures and pressures, it needs very high energies in order to strip the electrons from the nucleus and to overcome the electromagnetic repulsion of the positive charges .
The fusion reaction rate increases rapidly with temperature until it maximizes and then gradually drops off. The DT rate peaks at a lower temperature (about 70 keV, or 800 million kelvin) and at a higher value than other reactions commonly considered for fusion energy.
Fusion experimentally, apart from the Hbomb, has been sustained at JET, an experimental facility, by confining a plasma at the high temperatures necessary, in a tokamak, a specially designed magnetic field. This design is extended into ITER which is a prototype fusion energy reactor, i.e, will give out more energy than spent in creating the magnetic field and the plasma. If you look at the links these are huge constructs not suitable for bombs.
A second direction in creating the plasma temperatures necessary for sustained fusion is with very strong lasers. If you look at the photo of the system needed to reach fusion energies again you will realize that it cannot become the central part of a bomb.
That is where present day technology is. Hopefully by the time nanotechnology catches up with fusion humanity will have matured enough to use fusion only for getting unlimited energy.