Physics Stack Exchange is a question and answer site for active researchers, academics and students of physics. It's 100% free.

Sign up
Here's how it works:
  1. Anybody can ask a question
  2. Anybody can answer
  3. The best answers are voted up and rise to the top

Is it possible to calculate the force exerted on a bound, infected red blood cell under various shear stresses? The strength of an adhesive interaction is normally measured by SPR or AFM, however using microfluidics, you can increase the shear stress until the cell dislodges, therefore, can you use this data to calculate force?

share|cite|improve this question
SPR and AFM might not be common abbreviations to everybody. – Bernhard Mar 29 '13 at 0:34
SPR - surface plasmon resonance and AFM - Atomic force microscopy. These methods normally measure the strength of binding between a purified receptor and ligand pair. However these methods are not representative of the interaction in vivo. That's why I am trying to find out if it's possible to determine the force needed to dislodge my parasites from my flow assays. – user22518 Apr 12 '13 at 13:58

Your Answer


By posting your answer, you agree to the privacy policy and terms of service.

Browse other questions tagged or ask your own question.