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The phenomenon of multi-photon ionization of atoms has been studied, both theoretically and experimentally, for several decades. Intense laser beam devices are the apparatuses used for the experimental study of this phenomenon.

QUESTION:

Would it be possible to use similar excitation processes with nuclei, using "low energy" $\gamma$-photons in order to manufacture nuclear isomers for industrial and medical applications?

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I don't see any fundamental reason why not, but the intensity requirements are going to be fierce, and I don't think that the sources are available. –  dmckee Mar 3 '13 at 22:06

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