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The phenomenon of multi-photon ionization of atoms has been studied, both theoretically and experimentally, for several decades. Intense laser beam devices are the apparatuses used for the experimental study of this phenomenon.


Would it be possible to use similar excitation processes with nuclei, using "low energy" $\gamma$-photons in order to manufacture nuclear isomers for industrial and medical applications?

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I don't see any fundamental reason why not, but the intensity requirements are going to be fierce, and I don't think that the sources are available. –  dmckee Mar 3 '13 at 22:06

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