Most famously, the "pillars of creation" part of the Eagle Nebula that appeared in the famous space telescope pictures, are thought to have probably been blown away by now. They are 6000 some lightyears away, and strong interstellar winds are eroding them, so if we could
be instantly transported there we might find them gone.
Also high mass stars have short lifetimes of only a few million years. And these are the ones we can see in distant galaxies. So in a galaxy say a hundred million light years away, the brightest stars we see should by now have all died (presumably replaced by new ones).
We can detect gamma ray bursts from several billion light years away (and they only last at most a few minutes).....