Assuming one spatial and one termporal dimension, let's assume an intertial transformation $A(v)$ as follows: $$ \begin{pmatrix} t' \\ x' \\ \end{pmatrix} = A(v) \begin{pmatrix} t \\ x \\ \end{pmatrix} $$ where $$ A(v) = e^{\sigma v} \begin{pmatrix} 1 & 0 \\ -v & 1 \\ \end{pmatrix} $$ for some constant $\sigma \ge 0$ (we get the Galileo transformation for $\sigma=0$ as a special case). It is simply a Galileo transformation combined with a velocity-dependent (and not reflection invariant, as shown below) global dilatation.
It can be easily shown, that $A(0) = 1$, $A^{-1}(v) = A(\bar v)$ with $\bar v=-v$ and $A(u)A(v)=A(w)$ with $w=u+v$, so $A(v)$ forms a group. The transformation is linear, as required by space homogeneity.
Following [1], if the space is isotropic, then $(t, -x)$ and $(t, -x')$ qualify as well for equivalent coordinates. Introducing the space reflection (parity) by the matrix $T=diag(1, -1)$, we can see, that $T A(v) T$ does not belong into the group (i.e. there is no $\bar v$ so that $T A(v) T = A(\bar v)$) unless $\sigma=0$ (then $\bar v=-v$), because $$ T A(v) T = e^{\sigma v} \begin{pmatrix} 1 & 0 \\ +v & 1 \\ \end{pmatrix} $$
In other words, if an event has coordiantes $(t, x)$ and $(t', x')$ in the two inertial frames, then for $\sigma > 0$ there is no inertial transformation (of the above form), that would connect $(t, -x)$ and $(t, -x')$, so the transformation $A(v)$ does not respect isotropy.
What is the physical meaning of the above $A(v)$ transformation for $\sigma > 0$? Does it mean that it depends on the axes orientation? How could an experiment be constructed to show that the space is not isotropic? This transformation must be preferring a space direction, but I would like to see this explicitly.
[1] Levy-Leblond, J.-M. (1976). One more derivation of the Lorentz transformation. American Journal of Physics, 44(3), 271–277.