If the Gibbs free energy equation is defined as:
∆G = ∆H - T∆S
And the amount of energy/work released from a reaction is:
-∆G = w_max
Living organisms use exergonic reactions to metabolize fuel where the Gibbs free energy is negative and they (can) occur spontaneously in non-living structures.
Also in living organisms the energy that is released from the exergonic reactions can be coupled with the endergonic reactions. These do not occur unless work is applied to the reagents.
Given that, is it possible for an endergonic reaction to happen anywhere outside of a living creature or man-made creation?