For a particle with spin 1/2, creating superpositions of up and down is easy: measure the particle's spin along the $x$ direction. This will collapse the state onto either of the states
$$|+\rangle=\frac{1}{\sqrt{2}}(|\uparrow\rangle+|\downarrow\rangle)\textrm{ or } |-\rangle=\frac{1}{\sqrt{2}}(|\uparrow\rangle-|\downarrow\rangle),$$
with the measurement outcome telling you which one was made.
Your second point is quite a bit more delicate. In an ideal case, our particle is sitting in empty space and not interacting with anything except whatever apparatus we use to manipulate it. That apparatus might indeed turn out to be a second particle, in which case, yes, the uncertainty principle forbids us from knowing its exact position+speed. This does not, however, imply that this will automatically put our state into a superposition. It means exactly that and nothing more. The outcome can still be perfectly determined, since all that really matters is that the energy (i.e. the hamiltonian) of the interaction be precisely known, as well as the time it was turned on for.
Your main misconception, however, is that unknown outcomes automatically mean superposition states, which is wrong. It is quite different to say the system is in the state $|+\rangle$ than to say it is 50% of the time in $|\uparrow\rangle$ and 50% in $|\downarrow\rangle$. With the first one, one can perform interference experiments, while the second one contains no information at all. Particularly, for evenly-weighted superposition states, the relative phase of the two components is crucial. If I have some superposition state of the form
$$
|\phi\rangle=\frac{1}{\sqrt{2}}(|\uparrow\rangle+e^{i\phi}|\downarrow\rangle),
$$
but I don't know what the phase $\phi$ is (which in practice means that I have a big box of states in different superpositions with $\phi$ evenly spread between $0$ and $2\pi$), then it's as good as a statistical mixture that can be prepared classically. Why is this? It's because each superposition state can be set up to make interference fringes that can be detected with enough particles. However, if I change the phase, it will offset the fringes by half a fringe spacing, so that if I take a long average I won't see any fringes at all. This means that you need a very controlled interaction to make useful superposition states.