# What is theory of Free Energy Perturbation? How is it applicable to chemical science?

What is theory behind free energy perturbation? Is it way too difficult to understand? Can someone explain it in simple terms.

-
Hi Chirag! If you started by saying what you have read on the topic and list what you do (and don't) understand, it would make it much easier for someone to answer at your level… For example, Wikipedia has a very nice page on this topic, so you could read that and come later ask more precise questions… –  F'x Sep 30 '12 at 7:56
Well what exactly I don't understand is... how is it statistically good practice to do forward and backward sampling in simulations based of FEP? PS: I'm not a statistician. –  Chirag Sep 30 '12 at 18:26