Given a metric
$$ ds^{2}~=~ g_{a,b}dx^{a}dx^{b}. $$
Here Einstein's summation convention is assumed for $a$ and $b$.
Then given the Laplacian over that metric, can then we find a metric $ g_{a,b} $ so
$$ \Delta _{g}f ~=~ - \nabla^2 f +V(x)f. $$
the first term on the left is the Laplacian operator in curvilinear coordinates.
the term on the right is just the ${\rm div}({\rm grad})f$ in Euclidean coordinates.
$V(x)$ is a potential in $n$-dimensions.
The idea, if this is possible, is to turn physical problems into geometrical problems, for example solving the Schroedinger equation would be equivalent to solve a Dirichlet problem for some Laplacian.