Here is a way an electrician solves the problem:
To get an analytical approximation let's approximate the large grid by a solid, homogenous metal sheet with thickness $H$.
Let 2 nodes be 2 cylindrical conductors of radius $r$ both. The distance between nodes, let it be $L$.
Also, for simplicity assume that the conductivity of the nodes is much greater than the conductivity of the sheet's material.
Because of the last assumption we can take that the nodes have a constant potential throughout their lengths. So, to determine the electric field we can consider an electrostatic problem:
Let the linear charge density on conductors be $±\lambda$.
Applying Gauss' theorem to one of the nodes, we find that the field strength of the node at a distance $l$ from its axis is equal to
$$E=\frac{\lambda}{2\pi\epsilon_0l}$$
The potential difference between the nodes are obtained by integration of the field:
$$U=\frac{\lambda}{2\pi\epsilon_0}\int_{r}^{L-r}\left ( \frac{1}{l}-\frac{1}{L-l}\right)dl\approx\frac{\lambda}{\pi\epsilon_0}\ln\frac{L}{r};L>>r$$
Assuming that the current density $j=\gamma E$ ($\gamma$ is sheet's conductivity) is constant over the thickness of the sheet, we obtain for the total current flowing out of a cylindrical node:
$$I=2\pi rHj=2\pi rH\gamma E=\frac{H\lambda\gamma}{\epsilon_0}$$
So, the resistance between 2 nodes approximately:
$$R=\frac{U}{I}\approx\frac{1}{\pi\gamma H}\ln\frac{L}{r}$$