Am I correct in assuming it is the weight of all that liquid + gravity?
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The weight of liquid impact will be minimal (since with a screw cap the force will be redirected along the screw threading) - it's the lubricating effect of the liquid that actually helps. You start unscrewing, the liquid gets into the threading and lubricates it. |
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The weight is caused by gravity. So, yes, gravity works for you if you turn the bottle upside-down. |
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