Ordinary matter and antimatter have the same physical properties when it comes to, for example, spectroscopy. Hydrogen and antihydrogen atoms produce the same spectroscopy when excited, and adsorb the same frequencies. The charge does not make a difference in the potential (regardless if it's generated by a proton or an antiproton) nor in how the positron behaves in this potential (being its mass equal to the mass of an electron)
How can astronomy evaluate if a far galaxy is made of matter or antimatter, given that from the spectroscopy point of view, they behave in the same way? In other words, how do we know that an asymmetry exists between matter and antimatter in the universe?